Testosterone Replacement Therapy (TRT)

There may be things about the hormonal imbalance that are affecting your quality of life. Could what you don’t know about hormonal imbalance be causing you discomfort? Is what you don’t know about hormonal imbalance degrading your life? Keep reading to learn more about hormonal imbalance and discover ways to improve your life. Testosterone is produced by both men and women but the amount produced by women is much smaller and the production comes from the adrenal glands. A decline in the testosterone level is associated with a decrease in sex drive and libido in both sexes. This condition is commonly observed in those with Adrenal Fatigue. Testosterone replacement therapy (TRT) re-energizes the entire body, increases lean muscle mass, and reverses the fat accumulation and muscular atrophy characteristic of aging in normal people. Unfortunately, the tricky thing about hormonal imbalance is that aggressive use of testosterone in Adrenal Fatigue can lead to overstimulation and eventually to adrenal crashes. get redirected here

 

About hormonal imbalance and adrenal fatigue

Pre-TRT workups should include a complete history and physical examination, together with a battery of blood tests including male hormonal profile and cancer screening tests such as prostate-specific antigen (PSA) to rule out any relative or absolute contraindications to testosterone replacement therapy. Various forms of synthetic testosterone have traditionally been used and these include oral, sublingual, intramuscular injection and transdermal patches. While these synthetic hormones have been widely used with beneficial effects, there are drawbacks to their use. Keep reading to learn even more about hormonal imbalance.

Oral synthetic preparations result in short-term elevation and undesirably high inter-individual and intra-individual variability of concentrations of testosterone. There are also commonly associated elevations of liver function tests and abnormalities at liver scans. Despite this, oral preparations still constitute about a third of prescriptions filled in the United States. Some common forms are pure testosterone, methyltestosterone, sublingual methyltestosterone and fluoxymesterone.e

The injectable synthetic testosterone is etherified. It is safe, effective, and the least expensive androgen preparation available. Learn more about hormonal imbalance treatment. Keep reading. When injected into a large muscle, it slowly absorbs and lasts longer, taking effect over several days to weeks. Injections eliminate the natural daily diurnal rhythm of testosterone production-high at night and early morning and low during the day. Testosterone enanthate and cypionate are forms commonly used and they have comparable pharmacokinetics. Both result in a supraphysiologic concentration of testosterone for one to four days after injection. A satisfactory regimen is to administer 200 mg of one of these esters once every two weeks intramuscularly, but a more physiologic replacement therapy would be 100 mg of one of these on a weekly basis.

Trans-dermal synthetic TRT systems are perhaps the most commonly used and they come in scrotal and non-scrotal forms. Clinical studies about hormonal imbalance have shown that both are effective forms of androgen replacement. The advantage of the scrotal form is that it produces high levels of circulating dihydrotestosterone (DHT) due to the high 5-alpha-reductase enzyme activity of scrotal skin and it requires shaving the scrotum. Inadequate scrotal size and adherence problems are limitations. Skin irritation does occur in those with sensitive skin. Non-scrotal skin patch’s advantage is that the serum testosterone concentration profile mimics the normal circadian variation observed in healthy young men. However, skin irritation is more common, with over 50 percent of users experiencing some form of site reaction sometimes during treatment. Pretreatment with corticosteroid creams (not the ointment forms) has been shown to reduce the severity and incidence of skin irritation without significantly affecting testosterone absorption from the patch helping us to learn more about hormonal imbalance treatments.

Progesterone (and Estrogen Dominance)

Estrogen and progesterone side effects work in synchronization with each other as checks and balances to achieve hormonal harmony in both sexes. It is not the absolute deficiency of estrogen or progesterone but rather the relative dominance of estrogen and relative deficiency of progesterone that is the main culprit in Adrenal Fatigue. Let us examine this in more detail.

What we know about hormonal imbalance is that while sex hormones such as estrogen and progesterone decline with age gradually, there is a drastic change in the rate of decline during the perimenopausal and menopausal years for the women in these two hormones.

From age 35 to 50, there is a 75% reduction in production of progesterone in the female body. Estrogen, during the same period, only declines about 35%. By menopause, the total amount of progesterone made in the body is extremely low, while estrogen is still present in the body at about half its pre-menopausal level. With the gradual drop in estrogen but severe drop in progesterone, there is insufficient progesterone to counteract the amount of estrogen in our body. This state is called Estrogen Dominance.

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